|
|
|
|
|
27th Zulqada 1435 | Monday, Sep 22, 2014
Health

Drug successfully treats low-grade ovarian cancer

Saturday, 9 February 2013
Comments(0)
Washington, February 09:

Researchers at the National Cancer Institute`s Gynecological Oncology Group have provided the first evidence of a drug that shows a relatively high response rate for low-grade ovarian cancer patients.

In the first-targeted therapy clinical trial for low-grade serous ovarian cancer, eight out of 52 (15 percent) patients had a complete or objective partial response (tumor shrinkage) and 34 (65 percent) had no disease progression during the two-year course of the study.

"These are remarkably encouraging results for what can ultimately be a devastating disease," paper`s senior author David Gershenson, M.D., professor in The University of Texas MD Anderson Cancer Center Department of Gynecological Oncology and Reproductive Medicine said.

These patients have a median overall survival of 80 months, about twice as long as those with high-grade disease, who are typically in their 60s when diagnosed and comprise 90 percent of ovarian cancer patients.

The average age of women with low-grade cancer falls in the early 40s, Gershenson said, and it`s not uncommon to see women in their 20s, 30s and 40s and the occasional teenager with the disease.

High-grade serous ovarian cancer is susceptible to chemotherapy upon relapse or recurrence.

Cancer-causing genetic mutations in BRAF and KRAS genes occur more frequently in low-grade ovarian cancer, so the researchers chose a drug that targets the molecular network that includes those genes.

Selumetinib inhibits MEK1/2, a critical molecule in what`s known as the MAPK pathway, which includes BRAF and KRAS.

All 52 patients had received at least one previous therapy, with 30 having had three or more.

Clinical trial results with selumetinib were quite satisfactory.

Median progression-free survival of 11 months and 34 patients (65 percent) went at least six months without their disease worsening.

Two-year overall survival of 55 percent.

Median overall survival had not been reached, because more than half of patients (61 percent) remained alive at the time of data cutoff for the study.

No treatment-related deaths were reported.

Side effects ranged from cardio and gastrointestinal toxicity to pain, fatigue, anemia and dermatological effects. Of the 52 patients, 22 had their doses reduced and 13 ultimately left the study due to side effects.

Researchers obtained tumor samples sufficient for DNA analysis from 34 patients. While 14 patients had KRAS mutations and two had BRAF mutations, there was no connection between having those mutations and whether the patients responded to selumetinib.

Gershenson said that the researchers will further explore the question of matching drug to mutation during a larger phase 2/3 clinical trial that he will lead with investigators from the NCI Gynecological Oncology Group and the United Kingdom.

The findings are published in the journal The Lancet Oncology.

ANI

Latest News

Estonia to clear bush along Russian border...

Estonian government has decided to clear the bush along the border between Estonia and Russia for full infrastructure development on border ...

Tariq Anwar hopeful of NCP, Cong alliance in Maharashtra

With Congress and NCP alliance for Maharashtra poll still undecided, NCP General Secretary Tariq An ...

Seven dead, more than one lakh affected in Meghalaya floods

At least seven persons were reported killed in Meghalaya’s South West Garo Hills district today a ...

Related News

WHO committee identifies more action to contain Ebola

The World Health Organisation (WHO) Monday said the second meeting of the emergency committee on the ...

Ebola toll hits 2,800: WHO

The deadliest Ebola virus disease epidemic in history has claimed 2,800 lives in West Africa, the World Health Organisat ...

Dengue cases now 75 in Delhi, nearby areas

The number of dengue cases in Delhi and its adjoining areas has climbed to 75, municipal officials s ...

Post new comment

To combat spam, please enter the code in the image.

Rs. 26190 (Per 10g)

Opinion Poll
Do you think Modi saying Muslims patriotic, a diplomatic statement?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, AP, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com