|
|
|
|
|
3rd Safarul Muzaffer 1436 | Thursday, Nov 27, 2014
Health

`Ketogenic diet` can ward off ageing: Study

Friday, 7 December 2012
Comments(0)
Washington, December 07:

A type of low-carb, low-calorie diet called "ketogenic diet" is rich in a compound that could delay the effects of ageing, scientists say.

Researchers in the laboratory of Gladstone Senior Investigator Eric Verdin, have identified the role that a chemical compound in the human body plays in the ageing process.

The mechanism may be key to new therapies for treating or preventing a variety of age-related diseases, including heart disease, Alzheimer`s and many forms of cancer.

Researchers examined the role of the compound beta-hydroxybutyrate (beta-OHB), a so-called "ketone body" produced during a prolonged low-calorie or ketogenic diet.

While ketone bodies such as beta-OHB can be toxic when present at very high concentrations in people with diseases such as Type I diabetes, researchers found that at lower concentrations, beta-OHB helps protect cells from "oxidative stress" ? which occurs as certain molecules build to toxic levels in the body and contributes to the ageing process.

"Here, we find that beta-OHB - the body`s major source of energy during exercise or fasting - blocks a class of enzymes that would otherwise promote oxidative stress, thus protecting cells from ageing," Verdin said in a statement.

Oxidative stress occurs as cells use oxygen to produce energy, but this activity also releases other potentially toxic molecules, known as free radicals.

As cells age, they become less effective in clearing these free radicals ? leading to cell damage, oxidative stress and the effects of ageing. Researchers found that beta-OHB might actually help delay this process.

In a series of laboratory experiments, the team administered beta-OHB in a chronic calorie-restricted diet.

The researchers found that calorie restriction spurs beta-OHB production, which blocked the activity of a class of enzymes called histone deacetylases, or HDACs.

Normally HDACs keep a pair of genes, called Foxo3a and Mt2, switched off, but increased levels of beta-OHB block the HDACs from doing so, which by default activates the two genes.

Once activated, these genes kick-start a process that helps cells resist oxidative stress. This discovery not only identifies a novel signalling role for beta-OHB, but it could also represent a way to slow the detrimental effects of ageing in all cells of the body.

"This breakthrough also greatly advances our understanding of the underlying mechanism behind HDACs, which had already been known to be involved in ageing and neurological disease," said co-author Katerina Akassoglou.

"The findings could be relevant for a wide range of neurological conditions, such as Alzheimer`s, Parkinson`s, autism and traumatic brain injury?diseases that afflict millions and for which there are few treatment options," Akassoglou said.

The study was published in the journal Science.

PTI

Latest News

NorthEast United crush Chennaiyin 3-0 in ISL

Hosts NorthEast United FC crushed Indian Super League (ISL) leaders Chennaiyin FC 3-0 at the Indira ...

Ryan Reynolds's dad's illness brought his family together

Actor Ryan Reynolds says his family grew closer when they discovered that his father had Parkinson's ...

11 headless bodies found in southern Mexico

Police found 11 headless bodies of young men Thursday on the road between Chilapa de Alvarez and Aya ...

Related News

India to formulate guidelines for tubercul...

The health ministry, with the Delhi-based All India Institute of Medical Sciences (AIIMS), will formulate clinical guidelines for managing t ...

Potter books help scientists understand how brain encodes stories

Scientists performed functional magnetic resonance imaging (fMRI) scans of eight people as they read ...

Copper essential for resting brain too

A new study has found that proper copper levels are essential to the health of the brain at rest. Copper has earlier ...

Post new comment

To combat spam, please enter the code in the image.

Rs. 26230 (Per 10g)

Opinion Poll
Do you think introduction of grills to separate ladies and gents in RTC buses add to travel woes?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, Telangana, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com