|
|
|
|
|
27th Zulqada 1435 | Tuesday, Sep 23, 2014
Health

Now, cancer-killing cells that can be injected into patients

Saturday, 5 January 2013
Comments(0)
London, January 05:

In a breakthrough, scientists have for the first time created cancer-killing cells which can be directly injected into patients.

Researchers in Japan have created cancer-specific killer T cells, the cells naturally occur in small numbers, but it is hoped injecting huge quantities back into a patient could turbo-charge the immune system, the `Daily Mail` reported.

Researchers at the RIKEN Research Centre for Allergy and Immunology revealed they have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, the `Daily Mail` reported.

To create these, the team first had to reprogramme T lymphocytes specialised in killing a certain type of cancer, into another type of cell called induced pluripotent stem cells (iPS cells).

These iPS cells then generated fully active, cancer-specific T lymphocytes. These lymphocytes regenerated from iPS cells could potentially serve as cancer therapy in the future, researchers believe.

Previous research has shown that killer T lymphocytes produced in the lab using conventional methods are inefficient in killing cancer cells mainly because they have a very short life-span, which limits their use as treatment for cancer.

To overcome the problems, Japanese researchers, led by Hiroshi Kawamoto reprogrammed mature human killer T lymphocytes into iPS cells and investigated how these cells differentiate.

The team induced killer T lymphocytes specific for a certain type of skin cancer to reprogramme into iPS cells by exposing the lymphocytes to the `Yamanaka factors` - a group of compounds that induce cells to revert to a non-specialised, stage.

The iPS cells obtained were then grown in the lab and induced to differentiate into killer T lymphocytes again. This new batch of T lymphocytes was shown to be specific for the same type of skin cancer as the original lymphocytes.

They maintained the genetic reorganisation, enabling them to express the cancer-specific receptor on their surface. The new T lymphocytes were also shown to be active and to produce an anti-tumour compound.

"We have succeeded in the expansion of antigen-specific T cells by making iPS cells and differentiating them back into functional T cells," Kawamoto said.

"The next step will be to test whether these T cells can selectively kill tumour cells but not other cells in the body. If they do, these cells might be directly injected into patients for therapy. This could be realised in the not-so-distant future," Kawamoto said.

The findings were published in the journal Cell Stem Cell.

PTI

Latest News

Serena Williams says playing less tennis helped her prolong her career

While acknowledging in the wake of Li Na's retirement that players' bodies can betray them, world nu ...

BJP refuses further comments over seat-sharing tussle with Shiv Sena

Bharatiya Janata Party (BJP) spokesperson Nalin Kohli on Tuesday said that while his party had put f ...

Google Launches Initiatives in Support of Digital India

Search giant Google yesterday said it is working with government to launch a nationwide contest for ...

Related News

Shun sedentary lifestyle to stay sharp

Engaging in physical activity and avoiding a sedentary lifestyle are both important for maintaining an adequate brain he ...

UN mission team to combat Ebola arrives in Africa

An advance team of the United Nations Mission for Ebola Emergency Response (UNMEER) has arrived in G ...

WHO committee identifies more action to contain Ebola

The World Health Organisation (WHO) Monday said the second meeting of the emergency committee on the ...

Post new comment

To combat spam, please enter the code in the image.

Rs. 26350 (Per 10g)

Opinion Poll
Do you think Modi saying Muslims patriotic, a diplomatic statement?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, AP, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com