|
|
|
|
|
6th Zulqada 1435 | Tuesday, Sep 02, 2014
Health

Protein behind dry and scaly skin in eczema discovered

Monday, 7 January 2013
Comments(0)
London, January 07:

Scientists including an Indian-origin researcher have discovered a malfunctioning protein that triggers dry, itchy and inflamed skin lesions in a common type of eczema.

Researchers at Oregon State University found that the protein Ctip2 that controls body fats that keep skin healthy and hydrated, can cause atopic dermatitis, a common type of eczema if it is not performing properly.

Eczema allows significant loss of fluids through the skin, allowing allergens to penetrate, the `Daily Mail` reported.

"In these studies, we`ve basically shown that inadequate Ctip2 is reducing the lipids in skin that it needs to stay healthy, protect itself and perform its function," Arup Indra, an associate professor in the OSU College of Pharmacy said.

"At the same time, this can allow unwanted formation of proteins that trigger inflammation," Indra said.

"The skin`s ability to resist inflammation is going down just as the amount of inflammation is going up, and the underlying reason is that Ctip2 is not doing its job. Either or both of these problems can lead to eczema," Indra added.

Atopic dermatitis is associated with a dysfunctional immune response, but researchers have not understood the underlying cause.

Existing treatments use moisturisers to try to protect skin, and in difficult cases powerful steroid drugs can help, but they often have significant unwanted side effects, especially in long-term use.

Most people outgrow it as they reach adulthood, but some suffer from the condition their entire life.

"Our skin is the largest organ in the human body and one of the most important," Indra said.

"It`s our first barrier of defence, is in a constant battle against external insults, is influenced by both genetics and the environment, and has to be finely tuned to do many jobs. In eczema, this process begins to break down," Indra added.

The study was published in journal PLoS ONE.

PTI

Latest News

Britain asks citizens to review travel pla...

The British Foreign and Commonwealth Office (FCO) has advised its citizens to review their planned trips to Pakistan in view of the volatile ...

We played a perfect game today, says Dhoni

India captain Mahendra Singh Dhoni feels his side played a "perfect game" today as the visitors thra ...

Rahane, Dhawan clinch ODI series for India

Ajinkya Rahane smashed his maiden ODI century as India clinched their first 50-over series win on En ...

Related News

AIIMS sees increase in eye donors

The eye bank of AIIMS has seen a rise in the number of donors in the last couple of years, an official said Tuesday. ...

Fear grips onlookers as Ebola victim walks through market

A video footage has emerged from Liberia showing a person tagged positive for Ebola virus disease (E ...

Kala-azar free India by 2015: Harsh Vardhan

Health Minister Harsh Vardhan Monday said that India aims to eliminate dreaded vector-borne disease ...

Post new comment

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Copy the characters (respecting upper/lower case) from the image.

Rs. 27530 (Per 10g)

Opinion Poll
Do you think KCR would continue celebrating all national events at Golconda Fort beginning from Independence Day?
YesNoCan't say

Comments >>

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, AP, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com