|
|
|
|
|
24th Shawwal 1435 | Thursday, Aug 21, 2014
Health

`Villain` stomach bug may help control diabetes

Saturday, 9 February 2013
Comments(0)
Washington, February 09:

A stomach bacterium which is believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach`s ecosystem and controlling body weight and glucose tolerance, researchers have claimed.

Usually the villain in studies of gastric cancer and peptic ulcers, Helicobacter pylori infect about half of the world`s population although most infected individuals don`t get sick.

The bacterium`s dwindling numbers coincide with the epidemic of obesity and diabetes in developed countries.

"H. pylori is the dominant member of the gastric microbiota and infects about half of the world population. While H. pylori infection can be associated with severe disease, it helps control chronic inflammatory, allergic, or autoimmune diseases," Josep Bassaganya-Riera, director of the Nutritional Immunology and Molecular Medicine Laboratory and the Center for Modeling Immunity to Enteric Pathogens (MIEP) at Virginia Tech said.

"We demonstrated for the first time that gastric colonization with H. pylori exerts beneficial effects in mouse models of obesity and diabetes," he said.

During the past 20 years, obesity in the United States has increased dramatically, according to the Centers for Disease Control and Prevention.

About 36 percent of US adults and approximately 17 percent of young people aged 2 to 19 years are obese. Obesity is the leading risk factor for type 2 diabetes and the rates of diabetes have increased in parallel with the rates of obesity.

Mice infected with H. pylori showed less insulin resistance than uninfected mice or other mice infected with a more virulent strain of H. pylori, according to the study.

Researchers believe that whether the infection is harmful or beneficial depends on the interaction between the genetic makeup of H. pylori and the host`s immune response.

H. pylori carrying the cytotoxin-associated gene pathogenicity island were harmful. But the bacteria with or without an atypical island may be integral to human stomach microbiota.

Indeed, studies show that humans have been colonized by H. pylori for about 116,000 years.

The role of H. pylori as a pathogen does not provide an explanation as to why it has colonized the stomach of humans thousands of years.

"Our new findings suggest that H. pylori may provide important metabolic traits required to ameliorate diabetes that humans have not evolved on their own," Bassaganya-Riera said.

This suggests that the overuse of antibiotics for everything from misdiagnosed infections in humans to supplementary livestock feed may destroy beneficial bacteria and contribute directly to diseases such as obesity, allergies, inflammatory bowel disease, and asthma.

It may be time for humans to reconsider how we can better co-exist with H. pylori and other microbes as a means of promoting health.

The findings are published in the journal PLOS One.

ANI

Latest News

Pakistan assembly rejects "unconstitutional demands" of PTI, PAT

Pakistan's National Assembly today rejected the demands by the Pakistan Tehreek-i-Insaf (PTI) and th ...

Two militant hideouts busted in Kashmir, a...

Security forces have busted two militant hideouts in Bandipora and Kupwara districts of Kashmir and recovered arms and ammunition, an Army s ...

Acceleration of economy likely this fiscal...

Standing on the crossroads, the Indian economy could travel down the bumpy lane to a faster highway but for the current fiscal (2014-15), th ...

Related News

Free Ayurvedic Consultation Camp

Rushipeetham Charitable Trust, founded by Brahmasri Samavedam Shanmukha Sarma, will be conducting a free Ayurvedic Consu ...

Removed AIIMS official to demand CBI inquiry

A day after Sanjeev Chaturvedi was removed from the post of chief vigilance officer (CVO) of AIIMS, ...

US doctor with Ebola to be released from hospital

An American doctor who contracted the Ebola virus disease while treating patients in West Africa wil ...

Post new comment

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Copy the characters (respecting upper/lower case) from the image.

Rs. 27730 (Per 10g)

Opinion Poll
Do you think KCR would continue celebrating all national events at Golconda Fort beginning from Independence Day?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, AP, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com