|
|
|
|
|
22nd Zulqada 1435 | Friday, Sep 19, 2014
Health

`Villain` stomach bug may help control diabetes

Saturday, 9 February 2013
Comments(0)
Washington, February 09:

A stomach bacterium which is believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach`s ecosystem and controlling body weight and glucose tolerance, researchers have claimed.

Usually the villain in studies of gastric cancer and peptic ulcers, Helicobacter pylori infect about half of the world`s population although most infected individuals don`t get sick.

The bacterium`s dwindling numbers coincide with the epidemic of obesity and diabetes in developed countries.

"H. pylori is the dominant member of the gastric microbiota and infects about half of the world population. While H. pylori infection can be associated with severe disease, it helps control chronic inflammatory, allergic, or autoimmune diseases," Josep Bassaganya-Riera, director of the Nutritional Immunology and Molecular Medicine Laboratory and the Center for Modeling Immunity to Enteric Pathogens (MIEP) at Virginia Tech said.

"We demonstrated for the first time that gastric colonization with H. pylori exerts beneficial effects in mouse models of obesity and diabetes," he said.

During the past 20 years, obesity in the United States has increased dramatically, according to the Centers for Disease Control and Prevention.

About 36 percent of US adults and approximately 17 percent of young people aged 2 to 19 years are obese. Obesity is the leading risk factor for type 2 diabetes and the rates of diabetes have increased in parallel with the rates of obesity.

Mice infected with H. pylori showed less insulin resistance than uninfected mice or other mice infected with a more virulent strain of H. pylori, according to the study.

Researchers believe that whether the infection is harmful or beneficial depends on the interaction between the genetic makeup of H. pylori and the host`s immune response.

H. pylori carrying the cytotoxin-associated gene pathogenicity island were harmful. But the bacteria with or without an atypical island may be integral to human stomach microbiota.

Indeed, studies show that humans have been colonized by H. pylori for about 116,000 years.

The role of H. pylori as a pathogen does not provide an explanation as to why it has colonized the stomach of humans thousands of years.

"Our new findings suggest that H. pylori may provide important metabolic traits required to ameliorate diabetes that humans have not evolved on their own," Bassaganya-Riera said.

This suggests that the overuse of antibiotics for everything from misdiagnosed infections in humans to supplementary livestock feed may destroy beneficial bacteria and contribute directly to diseases such as obesity, allergies, inflammatory bowel disease, and asthma.

It may be time for humans to reconsider how we can better co-exist with H. pylori and other microbes as a means of promoting health.

The findings are published in the journal PLOS One.

ANI

Latest News

Tippu Shaheed Institute Hubli observes Eng...

Tippu Shaheed Institute of Technology [Polytechnic] Hubli observed Engineer’s day on the birth anniversary of Sir M. Visvesvaraya here on ...

Life empowering workshop for students

A ten-day workshop on “discover memory, conquer exams” will be organized by CIGMA India, here from October 5, for th ...

Indian Muslims will live and die for India: Modi

Indian Muslims will live and die for India, Prime Minister Narendra Modi has said, maintaining that ...

Related News

Smoking can cause urologic diseases: experts

Cigarette smoking can lead to a number of urological diseases and only a few people are aware of thi ...

Smoking causes urological diseases

Smoking leads to a number of urological diseases, experts said. Reduced fertility, impotence, and bladder carcinoma a ...

No ebola case reported in Malaysia: Minister

Malaysian Health Minister S. Subramaniam Friday said that no case of the Ebola Virus Disease (EVD) has been reported in the country and ther ...

Post new comment

To combat spam, please enter the code in the image.

Rs. 26340 (Per 10g)

Opinion Poll
Do you think attack on rescuers in Srinagar justified?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, AP, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com