|
|
|
|
|
3rd Zulqada 1435 | Saturday, Aug 30, 2014
Health

Why morphine increases pain in some patients

Monday, 7 January 2013
Comments(0)
Washington, January 07:

Researchers are closer to finding out the reason why certain adults and children’s pain gets worse when they treated with morphine.

“Our research identifies a molecular pathway by which morphine can increase pain, and suggests potential new ways to make morphine effective for more patients,” senior author Dr. Yves De Koninck, Professor at Universite Laval in Quebec City said.

The team included researchers from The Hospital for Sick Children (SickKids) in Toronto, the Institut universitaire en sante mentale de Quebec, the US and Italy.

The research not only identifies a target pathway to suppress morphine-induced pain but teases apart the pain hypersensitivity caused by morphine from tolerance to morphine, two phenomena previously considered to be caused by the same mechanisms.

“When morphine doesn’t reduce pain adequately the tendency is to increase the dosage. If a higher dosage produces pain relief, this is the classic picture of morphine tolerance, which is very well known. But sometimes increasing the morphine can, paradoxically, makes the pain worse,” co-author Dr. Michael Salter, Senior Scientist and Head of Neurosciences and Mental Health at SickKids, Professor of Physiology at University of Toronto, and Canada Research Chair in Neuroplasticity and Pain said.

“Pain experts have thought tolerance and hypersensitivity (or hyperalgesia) are simply different reflections of the same response,” Dr. De Koninck said, “but we discovered that cellular and signalling processes for morphine tolerance are very different from those of morphine-induced pain.”

Dr. Salter added, “We identified specialized cells – known as microglia – in the spinal cord as the culprit behind morphine-induced pain hypersensitivity. When morphine acts on certain receptors in microglia, it triggers the cascade of events that ultimately increase, rather than decrease, activity of the pain-transmitting nerve cells.”

The researchers also identified the molecule responsible for this side effect of morphine.

“It``s a protein called KCC2, which regulates the transport of chloride ions and the proper control of sensory signals to the brain,” Dr. De Koninck said.

“Morphine inhibits the activity of this protein, causing abnormal pain perception. By restoring normal KCC2 activity we could potentially prevent pain hypersensitivity.”

The research is published in the on-line edition of Nature Neuroscience.

ANI

Latest News

BJP on back foot, does not want elections in Delhi, says Tariq Anwar

Nationalist Congress Party ( NCP) leader Tariq Anwar on Saturday alleged that the Bharatiya Janata P ...

Muhammad Abdul Muqueet Chanda made Sadasiv...

Muhammad Abdul Muqueet Chanda district president TRS Minority Cell has been appointed as Sadasivapet Mandal incharge. This move has been tak ...

Love-jihad case:Rakibul Hussain supplied girls to high profile people, s...

Making a shocking revelation in Tara Shahdeo's alleged Love-jihad case, the national shooter's husba ...

Related News

Your face can reveal your heart condition

The facial features of an individual can reflect whether or not a person is experiencing atrial fibr ...

Damp and mould in homes put asthmatics at greater risk

A new study has revealed that damp and mould in homes could pose a significant health risk to people ...

'Unnecessary' respiratory infection controls heighten ebola pa...

A new study has found that excessive respiratory infection precautions for ebola patients are "uncom ...

Post new comment

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Copy the characters (respecting upper/lower case) from the image.

Rs. 27730 (Per 10g)

Opinion Poll
Do you think KCR would continue celebrating all national events at Golconda Fort beginning from Independence Day?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, AP, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com