|
|
|
|
|
7th Rabi-us-Saani 1436 | Wednesday, Jan 28, 2015
Health

Why morphine increases pain in some patients

Monday, 7 January 2013
Comments(0)
Washington, January 07:

Researchers are closer to finding out the reason why certain adults and children’s pain gets worse when they treated with morphine.

“Our research identifies a molecular pathway by which morphine can increase pain, and suggests potential new ways to make morphine effective for more patients,” senior author Dr. Yves De Koninck, Professor at Universite Laval in Quebec City said.

The team included researchers from The Hospital for Sick Children (SickKids) in Toronto, the Institut universitaire en sante mentale de Quebec, the US and Italy.

The research not only identifies a target pathway to suppress morphine-induced pain but teases apart the pain hypersensitivity caused by morphine from tolerance to morphine, two phenomena previously considered to be caused by the same mechanisms.

“When morphine doesn’t reduce pain adequately the tendency is to increase the dosage. If a higher dosage produces pain relief, this is the classic picture of morphine tolerance, which is very well known. But sometimes increasing the morphine can, paradoxically, makes the pain worse,” co-author Dr. Michael Salter, Senior Scientist and Head of Neurosciences and Mental Health at SickKids, Professor of Physiology at University of Toronto, and Canada Research Chair in Neuroplasticity and Pain said.

“Pain experts have thought tolerance and hypersensitivity (or hyperalgesia) are simply different reflections of the same response,” Dr. De Koninck said, “but we discovered that cellular and signalling processes for morphine tolerance are very different from those of morphine-induced pain.”

Dr. Salter added, “We identified specialized cells – known as microglia – in the spinal cord as the culprit behind morphine-induced pain hypersensitivity. When morphine acts on certain receptors in microglia, it triggers the cascade of events that ultimately increase, rather than decrease, activity of the pain-transmitting nerve cells.”

The researchers also identified the molecule responsible for this side effect of morphine.

“It``s a protein called KCC2, which regulates the transport of chloride ions and the proper control of sensory signals to the brain,” Dr. De Koninck said.

“Morphine inhibits the activity of this protein, causing abnormal pain perception. By restoring normal KCC2 activity we could potentially prevent pain hypersensitivity.”

The research is published in the on-line edition of Nature Neuroscience.

ANI

Latest News

Tibetan spiritual leader the Dalai Lama on Tuesday said although he did not support nuclear weapons ...

IB cites security reasons for off-loading Greenpeace activist

"National security considerations" were cited as the key reason by the Intelligence Bureau (IB) for ...

Pakistan wants normal ties with 'important neighbour' India: P...

Pakistan's High Commissioner to India, Mr. Abdul Basit, called on Prime Minister Muhammad Nawaz Shar ...

Related News

Negative doctor-patient talks can worsen symptoms

Doctors who unintentionally tell patients that they do not believe or understand them could actually ...

Want to quit smoking? Do it gradually

If you made a new year resolution to no longer take those tobacco puffs, tweak your plans a bit as a new study says that ...

Oxfam: Rich countries must support Ebola r...

Rich countries must act swiftly to repair battered health systems and get cash to millions of families in the three countries hit hardest by ...

Post new comment

To combat spam, please enter the code in the image.

Rs. 27600 (Per 10g)

Opinion Poll
Do you think Kiran Bedi is a safe bet for BJP against a strong Kejriwal?
YesNoCan't say

Matrimony | Photos | Videos | Search | Polls | Archives | Advertise | Letters

© The Siasat Daily, 2012. All rights reserved.
Jawaharlal Nehru Road, Abids, Hyderabad - 500001, Telangana, India
Tel: +91-40-24744180, Fax: +91-40-24603188
contact@siasat.com