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Fasting-mimicking diet may reverse diabetes: study

Washington: A diet designed to imitate the effects of fasting may reverse diabetes by reprogramming cells, claims a new study that may help treat the condition without drugs or painful insulin injections.

The fasting-like diet promotes the growth of new insulin-producing pancreatic cells that reduce symptoms of type 1 and type 2 diabetes in mice, according to the study on mice and human cells led by researchers at University of Southern California (USC) in the US.

“Cycles of a fasting-mimicking diet and a normal diet essentially reprogrammed non-insulin-producing cells into insulin-producing cells,” said Valter Longo, director of the Longevity Institute at the USC.

“By activating the regeneration of pancreatic cells, we were able to rescue mice from late-stage type 1 and type 2 diabetes. We also reactivated insulin production in human pancreatic cells from type 1 diabetes patients,” said Longo.

The reprogrammed adult cells and organs prompted a regeneration in which damaged cells were replaced with new functional ones, he said.

The research is the latest in a series of studies to demonstrate promising health benefits of a brief, periodic diet that mimics the effects of a water-only fast.

In type 1 and late-stage type 2 diabetes, the pancreas loses insulin-producing beta cells, increasing instability in blood sugar levels.

The study showed a remarkable reversal of diabetes in mice placed on the fasting-mimicking diet for four days each week.

They regained healthy insulin production, reduced insulin resistance and demonstrated more stable levels of blood glucose. This was the case even for mice in the later stages of the disease.

The diet cycles switched on genes in the adult mice that are normally active only in the developing pancreases of foetal mice.

The genes set off production of a protein, neurogenin-3 (Ngn3); thus, generating new, healthy insulin-producing beta cells.

Longo and his team also examined pancreatic cell cultures from human donors and found that, in cells from type 1 diabetes patients, fasting also increased expression of the Ngn3 protein and accelerated insulin production.

The results suggest that a fasting-mimicking diet could alleviate diabetes in humans.

Another study by the same team published last week demonstrated that the fasting-mimicking diet reduced risks for cancer, diabetes, heart disease and other age-related diseases in human study participants who followed the special diet for five days each month in a three-month span.

Prior studies on the diet have shown potential for alleviating symptoms of the neurodegenerative disease multiple sclerosis, increasing the efficacy of chemotherapy for cancer treatments, and decreasing visceral fat, researchers said.

The study was published in the journal Cell.

PTI