Toronto :Rehearsing in the brain after learning something new can help solidify memory by stimulating electrical activity in the brain, according to a new finding that may help treat memory disorders in people.
The permanence of memories has long thought to be mediated solely by the production of new proteins.
However, new research from the University of Alberta has shown that the electrical activity of the brain may be a more primary factor in memory solidification.
“It’s not just protein synthesis, long the dominant biological model, but also ‘offline’ memory rehearsal in the brain that leads to memory solidification,” said Clayton Dickson, psychology professor at the University of Alberta and one of the authors of the new study.
“Although the protein synthesis idea is entrenched in the field, we and others have been closely examining the older data that supports this and have found some perplexing inconsistencies,” said Dickson.
“Learning is thought to occur ‘online’ by creating new or strengthened synaptic connections,” said Dickson.
“However, we also know that the period directly following learning – when the brain is ‘offline’ – is critical for solidifying that information,” he said.
Although agents that block protein synthesis can block future retrieval of this information at this stage, Dickson has long been convinced that this might be caused by disruption of electrical activity.
He equates this stage to a mental rehearsal of the preceding events, activity patterns that likely help set the memory in the subject’s brain.
The stage when a brain is actively engaged in a new experience can be described as “online” activity.
On the flip side of this neurological process, “offline” activity, or neural replay, is the process by which the brain rehearses what has been learned in order to strengthen the most important memories.
What Dickson and his collaborators have shown is that protein synthesis inhibitors disrupt activity and can also disrupt “online” processing as well.
“Memory permanence is a critical element of our day-to-day lives,” said Dickson.
“Understanding how our brains solidify memories is essential for treating memory disorders and, in the case of post-traumatic stress disorder, for potentially ridding oneself of bothersome memories,” he said.
“The more we understand about the process, the more likely we can find a way for people to improve their good memories and eliminate the bad,” Dickson added.
The study was published in The Journal of Neuroscience.
PTI