Cancer patient gives birth from eggs matured, frozen in lab

Paris: Fertility doctors in France have announced the birth of the first baby to be born to a cancer patient from an immature egg that was matured in the laboratory, frozen, then thawed and fertilised five years later.

A recent paper in the leading cancer journal — Annals of Oncology — describes how the baby boy was born to a 34-year-old French woman, who was infertile because she had been treated with chemotherapy for breast cancer five years earlier.

Before she started her cancer treatment, doctors removed seven immature eggs from her ovaries and used a technique called in vitro maturation (IVM) to enable the eggs to develop further in the laboratory.

The mature eggs were then frozen by means of vitrification, which freezes the eggs very rapidly in liquid nitrogen to reduce the chances of ice crystals forming and damaging the cell.

Until now, there have been no successful pregnancies in cancer patients after eggs that have undergone IVM and vitrification, although some children have been born as a result of IVM followed by immediate fertilisation and transfer to the patient without freezing.

Prof Michael Grynberg, Head of the Department of Reproductive Medicine and Fertility Preservation at the Antoine Beclere University Hospital, France, said: “I saw the 29-year-old patient following her diagnosis of cancer and provided fertility counselling. I offered her the option of egg freezing after IVM and also freezing ovarian tissue. She rejected the second option, which was considered too invasive a couple of days after a cancer diagnosis.”

Ultrasound revealed there were 17 small fluid-filled sacs containing immature eggs in her ovaries. However, using hormones to stimulate her ovaries to ripen the eggs would have taken too long and could have made her cancer worse.

Therefore, an emergency procedure was scheduled six days later without ovarian stimulation, and Prof Grynberg retrieved seven immature eggs before her chemotherapy started.

After five years, the patient had recovered from breast cancer but found the chemotherapy had made her infertile as she had been unable to conceive within a year. Stimulating her ovaries to prompt them to produce more eggs run the risk that the hormones used could cause breast cancer to recur, so she and her doctors decided to use her frozen eggs.

All six eggs survived the thawing process and they were fertilised using ICSI (intracytoplasmic sperm injection). Five eggs were fertilised successfully and one embryo was transferred to the patient’s womb. She became pregnant and nine months later she gave birth to a healthy baby boy called Jules on 6 July 2019.

Grynberg suggested that “fertility preservation should always be considered as part of the treatment for young cancer patients. Egg or embryo vitrification after ovarian stimulation is still the most established and efficient option.”

“However, for some patients, ovarian stimulation isn’t feasible due to the need for urgent cancer treatment or some other contraindication. In these situations, freezing ovarian tissue is an option but requires a laparoscopic procedure and, in addition, in some diseases, it runs the risk of reintroducing malignant cells when the tissue is transplanted back into the patient.”

“We are aware that eggs matured in the lab are of lower quality when compared to those obtained after ovarian stimulation. However, our success with Jules shows that this technique should be considered a viable option for female fertility preservation, ideally combined with ovarian tissue cryopreservation as well,” he concluded.

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