Washington: Phantom genes are not the ones that help produce protein in our cells and eventually in our bodies.
Earlier scientists suggested that LncRNAs had no pivotal role in cells. However, recent research has come up with the fact that one such LncRNAs termed ‘LincIRS2’ plays a major role in safeguarding our metabolism as its loss favours the development of metabolic complications in mice.
The study got published these new findings in the prestigious journal Nature Communications.
“In my estimate, only the function of less than 100 of the nearly 60,000 LncRNAs encoded in our genomes has been truly understood,” says Jan-Wilhelm Kornfeld, Danish Diabetes Academy (DDA) professor for Molecular Biology of Metabolic Diseases at University of Southern Denmark.
In clear comparison, researchers have largely understood the function of the 20,344 genes that encode proteins. That’s why it’s so exciting that we were able to identify the key role of this particular LncRNA using mice as a model organism, he says.
Using the ‘molecular scissor’ CRISPR/Cas9, Jan-Wilhelm Kornfelds research team succeeded in cutting out LincIRS2 from the mouse’s genome. Next, the researchers observed that mice lacking LincIRS2 developed metabolic complications like elevated blood sugar levels when the LncRNA had been deactivated. Conversely, when performing treatments that activate LincIRS2, mice maintained healthy blood sugar levels even when becoming obese.
It is difficult to predict exactly how this new knowledge can be used, but it is intriguing to speculate that restoring or inhibiting specific LncRNAs could be used to treat diabetic patients or other metabolic disorders one day, says Jan-Wilhelm Kornfeld.
The lead author of the article is Dr. Marta Pradas-Juni, who is a postdoc in Jan-Wilhelm Kornfelds’ research team.
DNA serves as a blueprint for producing proteins that constitute the essential building blocks all cells are made of. The molecular intermediary that converts DNA information into proteins is called RNA. Thus, RNA’s primary purpose is to translate the ‘genes’ DNA into protein.
In our bodies, 20,344 different genes are specifically designed to create the many different proteins that our bodies require. The majority of these so-called protein-coding RNAs have been mapped by scientists. That is why, we today largely understand exactly which proteins these RNAs give rise to.
However, nearly 60,000 RNAs called ‘RNA”>Long noncoding RNAs’ are written into our genomes that never contribute to the formation of a protein. How they function, and how they are involved in disease development is largely unknown.