Australia beat Pakistan by 92 runs in the first one-day international at the Gabba on Friday.
Matthew Wade scored a last-ball 100 to lead Australia to 268 for nine off their 50 overs.
James Faulkner took four wickets for 32 to help Australia dismiss Pakistan for 176 off 42.4 overs.
Pakistan were well placed when they had Australia at 78-5 before Wade and Glenn Maxwell (60) put on 82 runs for the sixth wicket to push on.
But the tourists could not put any pressure on the Australians in their innings with skipper Azhar Ali injuring a hamstring and Babar Azam topscoring with 33.