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Mouse eggs from stem cells grown by scientists in laboratory

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Paris: Japanese scientists have said that they have been successful in growing mouse eggs entirely in the labratory. They also successfully fertilized the eggs to yield fertile offspring. This is the first time that scientists have performed such expertise in human reproduction.

Scientists say that the technique – which involved coaxing stem cells into becoming mature eggs – was very much risky and controversial to be reproduced in humans eariler.

“This is the first report of anyone being able to develop fully mature and fertilizable eggs in a laboratory setting right through from the earliest stages of oocyte (immature egg) development,” commented Richard Anderson of the University of Edinburgh’s MRC Centre for Reproductive Health.

While the technique may be useful to treat infertility “one day”, the paper also showed “the complexity of the process and how it is a long way from being optimized,” he said via the Science Media Centre in London.

Only a small number of embryos which grew from the eggs developed into normal mice. The lab-grown eggs were more likely to have chromosomal abnormalities.

The authors of the paper – published in the science journal Nature – reported using two types of stem cell, which are neutral, juvenile cells that can become most any type of specialized cell of the body.

The first kind was harvested directly from mouse embryos, the team said, and the other created in the lab by reprogramming cells taken from mouse tail tips back into a juvenile state from which they can re-specialize.

The stem cells were grown into mature eggs, which were fertilized in the lab as well. The resulting embryos were then transferred into surrogate mice.

Of those that survived, both male and female pups were fertile and produced another generation of mice, the authors reported.

PTI

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