Previous coronaviruses infection may lessen severity of Covid-19

New York, Oct 7 : Being previously infected with a coronaviruses that cause the ‘common cold’ may decrease the severity of (SARS-CoV-2) infections, the virus behind Covid-19, say researchers, including one of Indian-origin.

The study, published in the Journal of Clinical Investigation, however, also demonstrated that the immunity built up from previous non-SARS-CoV-2 coronavirus infections does not prevent individuals from getting Covid-19.

The findings provide important insight into the immune response against SARS-CoV-2, which could have significant implications on Covid-19 vaccine development.

“Our results show that people with evidence of a previous infection from a “common cold” coronavirus have less severe Covid-19 symptoms,” said study author Manish Sagar from Boston University in the US.

While SARS-CoV-2 is a relatively new pathogen, there are many other types of coronaviruses that are endemic in humans and can cause the “common cold” and pneumonia.

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These coronaviruses share some genetic sequences with SARS-CoV-2, and the immune responses from these coronaviruses can cross-react against SARS-CoV-2.

In this study, the researchers looked at electronic medical record data from individuals who had a respiratory panel test (CRP-PCR) result between May 18, 2015 and March 11, 2020.

The CRP-PCR detects diverse respiratory pathogens including the endemic “common cold” coronaviruses. They also examined data from individuals who were tested for SARS-CoV-2 between March 12, 2020 and June 12, 2020.

After adjusting for age, gender, body mass index, and diabetes mellitus diagnosis, Covid-19 hospitalized patients who had a previous positive CRP-PCR test result for a coronoavirus had significantly lower odds of being admitted to the intensive care unit (ICU), and lower trending odds of requiring mechanical ventilation during Covid.

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The probability of survival was also significantly higher in Covid-19 hospitalized patients with a previous positive test result for a “common cold” coronoavirus.

However, a previous positive test result for a coronavirus did not prevent someone from getting infected with SARS-CoV-2.

Another interesting finding, the authors noted, is that immunity may prevent disease (Covid-19) in ways that are different from preventing infection by SARS-CoV-2.

This is demonstrated by the fact that the patient groups had similar likelihoods of infection but differing likelihoods of ending up in the ICU or dying.

Disclaimer: This story is auto-generated from IANS service.

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