Indianapolis: Researchers at the Indiana University School of Medicine have discovered a particular molecule that can improve lung function for people with asthma and food allergies.
The findings of the research were published in the journal, ‘Science Immunology’.
“Millions of children and adults in the United States have asthma, which results from allergen-induced inflammation in the lungs,” said Mark Kaplan, PhD, chair of the Department of Microbiology and Immunology and the senior author of the study.
“The ability of cells to communicate with each other is critical in the development of inflammation and occurs through the release of molecules called cytokines,” he added
One of these cytokines, interleukin-9 (IL-9), has been found in patients with asthma and food allergies, but how IL-9 promotes inflammation has been unclear. In the study published recently in Science Immunology, researchers define one of the cell types, called the lung macrophage, as a major target of IL-9.
They found allergic lung inflammation decreased when the receptor for IL-9 was missing and the macrophage is critical for IL-9 function in the allergic lung.
They also defined downstream effectors of IL-9 in the macrophage, identifying enzymes and additional cytokines that are required for the development of allergic inflammation, and found a correlation between IL-9 and the downstream effectors with the diagnosis of asthma in patients.
“This work is a significant advancement in our study of allergic lung inflammation,” Kaplan said.
“We can use this information to further study the macrophage populations and determine how it could be a potential therapeutic approach for the treatment of asthma and other types of lung inflammation,” he concluded.